Cosimo Posth, He Yu, Ayshin Ghalichi, Hlne Rougier, Isabelle Crevecoeur, Yilei Huang, Harald Ringbauer, Adam B. Rohrlach, Kathrin Ngele, Vanessa Villalba-Mouco, Rita Radzeviciute, Tiago Ferraz, Alexander Stoessel, Rezeda Tukhbatova, Dorothe G. Drucker, Martina Lari, Alessandra Modi, Stefania Vai, Tina Saupe, Christiana L. Scheib, Giulio Catalano, Luca Pagani, Sahra Talamo, Helen Fewlass, Laurent Klaric, Andr Morala, Mathieu Ru, Stphane Madelaine, Laurent Crpin, Jean-Baptiste Caverne, Emmy Bocaege, Stefano Ricci, Francesco Boschin, Priscilla Bayle, Bruno Maureille, Foni Le Brun-Ricalens, Jean-Guillaume Bordes, Gregorio Oxilia, Eugenio Bortolini, Olivier Bignon-Lau, Grgory Debout, Michel Orliac, Antoine Zazzo, Vitale Sparacello, Elisabetta Starnini, Luca Sineo, Johannes van der Plicht, Laure Pecqueur, Gildas Merceron, Graldine Garcia, Jean-Michel Leuvrey, Coralie Bay Garcia, Asier Gmez-Olivencia, Marta Potowicz-Bobak, Dariusz Bobak, Mona Le Luyer, Paul Storm, Claudia Hoffmann, Jacek Kabaciski, Tatiana Filimonova, Svetlana Shnaider, Natalia Berezina, Borja Gonzlez-Rabanal, Manuel R. Gonzlez Morales, Ana B. Marn-Arroyo, Beln Lpez, Carmen Alonso-Llamazares, Annamaria Ronchitelli, Caroline Polet, Ivan Jadin, Nicolas Cauwe, Joaquim Soler, Neus Coromina, Isaac Ruf, Richard Cottiaux, Geoffrey Clark, Lawrence G. Straus, Marie-Anne Julien, Silvia Renhart, Dorothea Talaa, Stefano Benazzi, Matteo Romandini, Luc Amkreutz, Herv Bocherens, Christoph Wiing, Sbastien Villotte, Javier Fernndez-Lpez de Pablo, Magdalena Gmez-Puche, Marco Aurelio Esquembre-Bebia, Pierre Bodu, Liesbeth Smits, Bndicte Souffi, Rimantas Jankauskas, Justina Kozakait, Christophe Cupillard, Hartmut Benthien, Kurt Wehrberger, Ralf W. Schmitz, Susanne C. Feine, Tim Schler, Corinne Thevenet, Dan Grigorescu, Friedrich Lth, Andreas Kotula, Henny Piezonka, Franz Schopper, Ji Svoboda, Sandra Szelov, Andrey Chizhevsky, Aleksandr Khokhlov, Nicholas J. Conard, Frdrique Valentin, Katerina Harvati, Patrick Semal, Bettina Jungklaus, Alexander Suvorov, Rick Schulting, Vyacheslav Moiseyev, Kristiina Mannermaa, Alexandra Buzhilova, Thomas Terberger, David Caramelli, Eveline Altena, Wolfgang Haak, Johannes Krause. DNA was extracted from the generated bone or tooth powder following established protocols. To bind DNA, silica columns for high volumes (High Pure Viral Nucleic Acid Large Volume Kit (Roche)) were used. 29, 11691177.e7 (2019). The effective population sizes (Ne) were then estimated using a maximum likelihood method, after filtering individuals with a signal of close-kin inbreeding (individuals with at least 50 cM of their genome in ROH spanning >20 cM) (Supplementary Information, section9). On the basis of PCA and outgroup f3-statistics, the Neolithic Tutkaul 1 individual from Tajikistan is closely related to Upper Palaeolithic individuals from south-central Siberia (Afontova Gora 3 (AG3) and Malta 1), and roughly contemporaneous West Siberian hunter-gatherers (Tyumen and Sosnoviy), both carrying high proportions of ANE ancestry45 (Fig. Natl Acad. 27, 18011810.e10 (2017). Nature (Nature) 1999 - 20001 year. This procedure allowed us to manually traverse the ISOGG Y-Haplogroup Tree, checking in a semi-automatic way which positions were covered. Karmin, M. et al. Currently use of the word 'vape' now means "to inhale and exhale the vapor produced by an . Soonafter8 ka, Sidelkino ancestry was absent in eastern Spain but it had already reached northern Iberia alongside an increase in Oberkassel ancestry (Fig. Even better your perks will stay yours even after you complete the course. and H. Ringbauer developed the contamination-estimation method. Check out Why is Burnout So Common in Tech? Late Pleistocene human genome suggests a local origin for the first farmers of central Anatolia. And if youre new to data science, check out the 365 Intro to Data and Data Science course. A Free Service of Your Local Public Library and the Pennsylvania Public Libraries Film Center of the State Library of Pennsylvania Touchstone Pictures In celebration of our twentieth animated feature, we invite you to relive with us the story telling magic, the wit, the wisdom, the humor, the understanding of a very special person who gave the world a timeless and universal art form. Protoc. PACEA co-authors of this research benefited from the scientific framework of the University of Bordeauxs IdEx Investments for the Future programme/GPR Human Past. Previously, she has interned at Goldman Sachs where she used Python and Scala to implement machine learning techniques for automated anomaly detection. We then attempted to model 250 published and newly reported hunter-gatherers dated to 145ka using qpAdm as a mixture of Oberkassel, Sidelkino, GoyetQ2 ancestries, and an ancestry maximized in Anatolian Neolithic farmers (ANF), as a considerable portion of the sequenced hunter-gatherer genomes date after around 8ka, when ANF ancestry started spreading across Europe. Mid and Late Upper Palaeolithic in the Adriatic Basin: chronology, transitions and human adaptations to a changing landscape. No, there are no prerequisites for enrolling. You also get a peek at Tina's Resume, so I don't think you want to miss out on that. Amazing content! Protoc. Some of those early groups from more than 40ka further admixed with Neanderthals, as shown by signals of recent introgression in individuals from Bacho Kiro in Bulgariaassociated with an Initial Upper Palaeolithic (IUP) archaeological cultureand from Petera cu Oase in Romania2,6. 14 following. 272, 288296 (2012). Genetic analyses of western European individuals associated with the preceding Badegoulian culture might provide clues on the processes that led to the formation of the GoyetQ2 cluster. Data Visualization Explained: Candlestick Chart, R Programming for Statistics and Data Science 2020. An equimolar pool of all libraries was then prepared for shotgun sequencing on Illumina Hiseq4000 platform using 75bp single-end reads for screening. performed or supervised laboratory work. Echinacea, also known as Coneflower, is legendary for a reason: science has shown multiple species of Echinacea can provide potentially broad-reaching support for the innate and adaptive immune system. 2 The distribution of mtDNA and Y-chromosome haplogroups among different hunter-gatherer groups. Publications 4. h-index 3. Ice Age survivors. The horizontal dashed line marks the boundary between Late Pleistocene and Holocene. I'm I've learned SQL before, but I need a refresher. Tina is a data scientist working in tech and does Youtube part time. The incoming Villabruna ancestry later became the most widespread hunter-gatherer ancestry across Europe. Typically, it calls for a great deal of data heavy-lifting and data visualizations with SQL and Python or R. A number of things can be done with traditional analysis, but it is machine learning that has taken an extremely solid place in product development. Population genomics of Mesolithic Scandinavia: investigating early postglacial migration routes and high-latitude adaptation. Raghavan, M. et al. Korlevi, P. et al. Lazaridis, I. et al. Thats it for today. & Strimmer, K. APE: analyses of phylogenetics and evolution in R language. 4 Admixture graph modelling of pre-34 ka hunter-gatherer lineages. The ethane yield of 35.4 mol/h with a high C 2 . The analysed genomes also show that the descendants of these Epigravettian inhabitants of the Italian peninsula spread across the rest of Europe about 14,000 years ago, replacing populations associated with the Magdalenian culture. 1, Extended Data Table 1, Supplementary Data 1.A, Supplementary Information, section1 and Supplementary Fig. In it, we laugh while discussing how to get started in data science and her learning/productivity tricks.Tina: Creates YouTube videos with millions of views on data science careers, learning to code, SQL, productivity, and study techniques. Is a data scientist at one of the world's largest tech companies (she keeps the firm anonymous so she can publish more freely). Previously worked at Goldman Sachs and the Ontario Institute for Cancer Research. Holds a Masters in Computer and Information Technology from the University of Pennsylvania and a bachelors in Pharmacology from the University of TorontoIn this episode, Tina details: Her guidance for preparing for a career in data science from scratch. Her five steps for consistently doing anything. Her strategies for learning effectively and efficiently. What the day-to-day is like for a data scientist at one of the worlds largest tech companies. The software languages she uses regularly. Her SQL course. How her science and computer science backgrounds help her as a data scientist today.Todays episode should be appealing to a broad audience, whether youre thinking of getting started in data science, are already an experienced data scientist, or youre more generally keen to pick up career and productivity tips from a light-hearted conversation.Thanks to Serg Mass, Brindha Ganesan and Ken Jee for providing questions for Tina in Ken's case, a very silly question indeed.The SuperDataScience show's available on all major podcasting platforms, YouTube, and at SuperDataScience.com. Admixture events were dated using the ancestry covariance pattern-based DATES 753 program105, with a bin size of 0.1 cM for covariance calculation and the start of exponential fitting at d0.5cM. Klaric, L., Goutas, N., Laccarire, J. Write a sharp and effective resume in minutes and get noticed by employers. The Kostenki genetic signature (related to the Kostenki 14 genome, and hereafter referred to as the Kostenkicluster or ancestry) contributed to the later Vstonice genetic cluster(hereafter,Vstonice cluster or ancestry), named after the Doln Vstonice site in Czechia4. (black) or 3s.e.m. Nature 582, 384388 (2020). Google Scholar. By submitting a comment you agree to abide by our Terms and Community Guidelines. Biol. This is also validated by f4-statistics of the form f4(Mbuti, Zlat k; test1, test2), which are consistent with zero for all other pre-LGM hunter-gatherers (Supplementary Data 2.C), indicating an equidistant relationship of Zlat k to the tested groups. My name is Tina Huang and Im a data scientist at a FAANG company. Contact Us. Alexis Bledel. Tina Huang. Furthermore, the gene pool of the western Gravettian populations is found continuously for at least 20,000 years: their descendants who are associated with the Solutrean and Magdalenian cultures stayed in southwestern Europe during the coldest period of the last Ice Age (between 25,000 and 19,000 years ago) and later spread north-eastward to the rest of Europe. 17, 60 (2016). 9). 27, 21852193.e6 (2017). Theyre both important sub-tasks for data scientists to master, but big data data warehousing and data science are only two components of the larger data science endeavor. CAS This course is presenting itself as both a refresher and a challenge. Where it all started :) I make weekly videos about self learning, practical productivity, and coding. Check out my courses where we apply scientifically backed learning techniques to accomplish our goals. Consistent with previous findings, none of the analysed groups show the derived allele at SNP rs4988235 on the LCT gene, which is responsible for lactase persistence. c, Admixture graph modelling of the main pre-LGM European hunter-gatherer lineages created using qpGraph. We report 47 new radiocarbon dates performed on skeletal elements of 40 individuals by the Curt-Engelhorn-Zentrum Archaeometrie in Mannheim (MAMS, n=29), Center for Isotope Research, University of Groningen (GrA and GrM, n=5), University of Aarhus (AAR, n=3), Beta Analytics (Beta, n=2), Zrich (ETH, n=3), International Chemical Analysis (ICA, n=2), Natural History Museum in Paris (Echo Lab, n=1) and Vilnius (FTMC, n=2) (Supplementary Data 1.A). 12, 5425 (2021). ADS I'm a data scientist and youtuber. 7 and Supplementary Table 3), which coincides roughly with the first appearance of the Oberkassel ancestry in central Europe. Genet. Int. This website is about taking one step at a time to ultimately live more fulfilling lives. Details of the grouping and ROH segments are provided in Data S3.B. Evol. We further validated the genetic distinction between the Vstonice and Fournol clusters observed in the MDS plot with a series of f4-statistics (Supplementary Data 2.B). Echinacea. First up is the MIT researcher and YouTuber Jordan Harrod. This was confirmed with qpAdm, in which we could model all individuals from the Oberkassel cluster as a broadly constant mixture of approximately 75% Arene Candide 16 and 25% Goyet Q-2 (or 90% Arene Candide 16 and 10% Fournol 85) (Fig. E.A. Her main topic is AI, exploring how it works and, most interestingly, how we increasingly interact with it in the world. Tina Huang, a data scientist currently working at a FAANG (Facebook, Amazon, Apple, Netflix, and Google Alphabet) company. The generation time is set to 29 years and the error bars show the SE of the admixture date estimated from jackknife resampling (n=22 autosomal chromosomes). Look here to get updated on my recent favourite books, animes, filming equipment and more! The 10 mock interviews provide a great detailed approach to solving any SQL questions. In her journey of eventually becoming a data scientist, Tina started out with an undergraduate in Pharmacology. Nature 505, 8791 (2014). 276, 107319 (2022). Pleistocene North African genomes link Near Eastern and sub-Saharan African human populations. Instagram has an infinite scroll, and Uber has different options such as UberXL and Uber Pool. After merging, individuals with less than 6,000 SNPs on 1240k sites were excluded from further analysis because of low coverage. The ancient human specimens analysed in this work derive from multiple scientific collaborations. 15, 22792300 (2020). a, MDS plot of pre-LGM individuals. 19-78-10053). All individuals belonging to the Fournol cluster show higher affinity to Goyet Q116-1 than to the Sunghir group (n=4), and the Vstonice-cluster individuals show higher affinity to the Sunghir group than to Goyet Q116-1 (Extended Data Fig. Piezonka, H. et al. Parallel palaeogenomic transects reveal complex genetic history of early European farmers. Shes the founder of Coding Black Females, a nonprofit with the aim to provide opportunities for Black female developers to develop themselves, meet familiar faces, network, receive support, and build relationships through having regular meetups., Check out the Coding Black Females website. Archaeological background, method descriptions and discussions additional to the main text, including sections 113, Figs. 132, Tables 14 and references. Thank you for visiting nature.com. Corporate Financial Managementspring term (BS 2508) Second year of undergraduate. 1c) and a west Eurasian principal component analysis (PCA) (Extended Data Fig. 2, e190 (2006). Nat. Surprisingly, however, none of those pre-40ka individuals left substantial traces in the genetic makeup of present-day Eurasian populations1,2,6,7. Goutas, N. in Les Gravettiens (ed. Taipei, Taiwan . This channel is about data science, learning, and productivity. Jnsson, H., Ginolhac, A., Schubert, M., Johnson, P. L. F. & Orlando, L. MapDamage2.0: fast approximate Bayesian estimates of ancient DNA damage parameters. 71, 465492 (2015). Save my name, email, and website in this browser for the next time I comment. Int. ScienceDaily, 1 March 2023. By the year 2014 however, 'vape' was named Oxford Dictionary's word of the year. Furthermore, we examined whether the patient's age, the etiology of their hearing loss, the depth of the electrode insertion, and a slow electrode insertion affect the result of postoperative speech audiometry (PSA). Nat. Subsequently, I worked in bioinformatics for a year and then did my Masters in computer science (MCIT) at the University of Pennsylvania. After another MinElute purification, the product was quantified using the Agilent 2100 Bioanalyzer DNA 1000 chip. Harris, K. & Nielsen, R. The genetic cost of Neanderthal introgression. . Svensson, E. et al. Google Scholar. This genetic signature is shared among individuals associated with the archaeologically defined Gravettian culture (3326ka) in central and southern Europe and seemingly disappeared after the Last Glacial Maximum4 (LGM). Newsletter, Djindjian, F. Territories and economies of hunter-gatherer groups during the last glacial maximum in Europe. Article Many students or recent graduates appreciate her for sharing what helped her break into the field. In no time, she established herself as one of the favorite vloggers of the data community. Tina is proud she taught herself SQL from scratch in 11 days to pass her FAANG SQL interview. In our interview with Tina Huang we were told the story of a student who wanted to learn to code. But she came up with a way to break down the code and create a website that she was proud of. Nat. The tree was calculated on 16,528 positions (partial deletion 95%) and with 500 bootstrap iterations using MEGA1097. What is Connection Map in Data Visualization? 864358 (to K.M. However, the extent to which groups associated with the Solutrean culture are in genetic continuity with earlier and later populations from the same region is unknown because no genomic data from Solutrean-associated individuals have been reported previously. To mark the occasion, rather than doing some data analysis or looking at trends, we wanted to dedicate this bulletin to seven women in tech, data, and science that you should know about. This study focuses on the people who lived between 35,000 and 5,000 years ago and that are, at least partially, the ancestors of the present-day population of Western Eurasia, including -- for the first time -- the genomes of people who lived during the Last Glacial Maximum (LGM), the coldest phase of the last Ice Age, around 25,000 years ago. These f4-statistics also confirm that Goyet Q376-3 carries a similar ancestry to Goyet Q116-1 and Kostenki 12 carries a similar ancestry to the Sunghir group, whereas Bacho Kiro 1653 (35ka) from Bulgaria, Muierii 1 (34ka) and Cioclovina 1 (32ka) from Romania, and Paglicci 133 (33ka) from southern Italy are equally related to Goyet Q116-1 and Sunghir. 15-star ratings) or unstructured data (such as social media reviews). This often involves analyzing similar products to compare how they performed. 9) and testing the relative affinity among them using f4-statistics in the form f4(Mbuti, Epigravettian A; Epigravettian B, Epigravettian C) (Supplementary Data 2.E). To obtain - Technical researcher and data analyst under the supervision of Dr. A. Meyer and Dr. S. Bae at UCLA. This figure shows that the Gravettian-associated individuals from western Europe (Fournol cluster) are closely related to Goyet Q116-1 while the Gravettian-associated individuals from central-eastern and southern Europe (Vstonice cluster) are closely related to the Sunghir group, representative of the Kostenki cluster. http://creativecommons.org/licenses/by/4.0/, Ancient genomes show how humans escaped Europes deep freeze. After 7.5ka, as ANF ancestry had reached regions north of the Alps, individuals carrying a hunter-gatherer genetic profile were primarily restricted to the northern fringes of Europe (Fig.

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